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KMID : 0385520090220040345
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Analytical Science & Technology
2009 Volume.22 No. 4 p.345 ~ p.353
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Elucidation of new anti-impotency analogue in food
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Suh Jung-Hyuck
Choi Jang-Duck
Park Kun-Sang
Hu Soo-Jung
Yoon Tae-Hyung
Kim Eun-Ju
Han Seung-Woo
Kim So-Hee
Lee Kwang-Ho
Kwon Sung-Won
Kim Deuk-Joon
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Abstract
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The new anti-impotency analogue was identified in food source. Detection of this analogue was accomplished through screening of food samples by liquid chromatography/photodiode array detector. The spectrum pattern of analogue compound was similar to that observed for hongdenafil which was analogue of sildenafil. This new compound was isolated and purified using the liquid-liquid extraction, thin layer chromatography, column chromatography and preparative HPLC. And then those structure were identified using analytical instruments such as HPLC/PDA, LC/MS/MS and NMR. The compound was given a name to oxohongdenafil which was replaced with acetyl oxoethylpiperazinyl residue instead of sulfonyl piperazine group of sildenafil. The regulation for the abovementioned analogue, oxohongdenafil, was established by Standard of Korean food code.
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KEYWORD
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anti-impotency, elucidation, food, regulation, oxohongdenafil
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